產(chǎn)品詳情介紹
粒細(xì)胞-巨噬細(xì)胞集落刺激因子（Granulocyte-Macrophage Colony-Stimulating Factor, GM-CSF）是一種重要的細(xì)胞因子，它在免疫反應(yīng)和炎癥過(guò)程中起著關(guān)鍵作用。GM-CSF主要促進(jìn)粒細(xì)胞和巨噬細(xì)胞的增殖、分化和活化，同時(shí)調(diào)控T細(xì)胞的響應(yīng)，對(duì)免疫系統(tǒng)的防御機(jī)制至關(guān)重要[1]。GM-CSF的表達(dá)受到精細(xì)的調(diào)控，這對(duì)于維持免疫平衡和防止自身免疫疾病的發(fā)展至關(guān)重要[2]。除了在免疫細(xì)胞中的重要作用，GM-CSF還可以通過(guò)激活p70 S6核糖體蛋白激酶信號(hào)通路來(lái)促進(jìn)中性粒細(xì)胞的趨化 [3]。GM-CSF的這些特性使其成為治療自身免疫疾病和炎癥性疾病的潛在靶點(diǎn)[4-5]。
[1] Shi Y, Liu CH, Roberts AI, Das J, Xu G, Ren G, Zhang Y, Zhang L, Yuan ZR, Tan HS, Das G, Devadas S. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and T-cell responses: what we do and don't know. Cell Res. 2006 Feb;16(2):126-33.
[2] Gasson JC, Fraser JK, Nimer SD. Human granulocyte-macrophage colony-stimulating factor (GM-CSF): regulation of expression. Prog Clin Biol Res. 1990;338:27-41.
[3] Gomez-Cambronero J, Horn J, Paul CC, Baumann MA. Granulocyte-macrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol. 2003 Dec 15;171(12):6846-55.
[4] Shiomi A, Usui T, Mimori T. GM-CSF as a therapeutic target in autoimmune diseases. Inflamm Regen. 2016 Jul 5;36:8. doi: 10.1186/s41232-016-0014-5.
[5] van Nieuwenhuijze A, Koenders M, Roeleveld D, Sleeman MA, van den Berg W, Wicks IP. GM-CSF as a therapeutic target in inflammatory diseases. Mol Immunol. 2013 Dec;56(4):675-82.
